I finally got a copy of Zbrush 4R2. It introduces some great features like dynamesh. (amongst other things.) It allows you to sculpt without worrying about topology. The only drawback is that it’s not designed for production with animation in mind. (from my understanding)
After you finish, you still have to go back in and retopo the model. I’ve read a few things on topogun, and I’m thinking about checking that out. If I do, I’ll update.